The quality of life is increasingly recognized as an important indicator of the outcomes of chronic diseases’ care.

CORESEARCH team has provided a remarkable contribution to the development, validation and dissemination of tools aimed at assessing the quality of life associated with public health (Health-Related Quality of Life), especially in the diabetes field.

The activities include the development and validation of new tools, sociocultural adaptation and validation of questionnaires developed in different languages, the application of quality of life measures in experimental and observational studies, the introduction of measures of quality of life in normal daily clinical practice and as a reference parameter of quality of care.

Among the ongoing activities, CORESEARCH acts as the Data Analysis Center for the Diabetes Attitudes, Wishes and Needs (DAWN-2) study, which involves 17 countries from 4 continents and coordinates the BENCH-D study, which involves 4 Italian regions.

 

Bibliography:

  1. Rossi MC, Lucisano G, Pintaudi B, Bulotta A, Gentile S, Scardapane M, Skovlund SE, Vespasiani G, Nicolucci A; BENCH-D Study Group.. The complex interplay between clinical and person-centered diabetes outcomes in the two genders. Health Qual Life Outcomes. 2017 Feb 21;15(1):41.
  2. Nefs G, Pouwer F, Holt RI, Skovlund S, Hermanns N, Nicolucci A, Peyrot M. Correlates and outcomes of worries about hypoglycemia in family members of adults with diabetes: The second Diabetes Attitudes, Wishes and Needs (DAWN2) study. J Psychosom Res. 2016 Oct;89:69-77.
  3. Giorda CB, Russo GT, Cercone S, De Cosmo S, Nicolucci A, Cucinotta D. Incidence and correlated factors of beta cell failure in a 4-year follow-up of patients with type 2 diabetes: a longitudinal analysis of the BETADECLINE study.  Acta Diabetol. 2016 Oct;53(5):761-7.
  4. Kovacs Burns K, Holt RI, Nicolucci A, Lucisano G, Skovlund SE, Comaschi M, Vallis M, Peyrot M. Correlates of psychological outcomes among family members of  people with diabetes in the second Diabetes Attitudes, Wishes and Needs (DAWN2(™) ) study. Diabet Med. 2016 Sep;33(9):1184-93
  5. Holt RI, Nicolucci A, Kovacs Burns K, Lucisano G, Skovlund SE, Forbes A, Kalra S, Menéndez Torre E, Munro N, Peyrot M. Correlates of psychological care strategies for people with diabetes in the second Diabetes Attitudes, Wishes and  Needs (DAWN2(™) ) study. Diabet Med. 2016 Sep;33(9):1174-83.
  6. Nicolucci A, Kovacs Burns K, Holt RI, Lucisano G, Skovlund SE, Kokoszka A, Massi Benedetti M, Peyrot M. Correlates of psychological outcomes in people with  diabetes: results from the second Diabetes Attitudes, Wishes and Needs (DAWN2(™)  ) study. Diabet Med. 2016 Sep;33(9):1194-203.
  7. Pintaudi B, Lucisano G, Gentile S, Bulotta A, Skovlund SE, Vespasiani G, Rossi MC, Nicolucci A; BENCH-D Study Group. Correlates of diabetes-related distress in type 2 diabetes: Findings from the benchmarking network for clinical and humanistic outcomes in diabetes (BENCH-D) study. J Psychosom Res. 2015;79:348-54.
  8. Rossi MC, Lucisano G, Funnell M, Pintaudi B, Bulotta A, Gentile S, Scardapane M, Skovlund SE, Vespasiani G, Nicolucci A; BENCH-D Study Group. Interplay among patient empowerment and clinical and person-centered outcomes in type 2 diabetes. The BENCH-D study. Patient Educ Couns. 2015;98:1142-9.
  9. Nicolucci A, Pintaudi B, Rossi MC, Messina R, Dotta F, Frontoni S, Caputo S, Lauro R. The social burden of hypoglycemia in the elderly. Acta Diabetol. 2015;52:677-85.
  10. Nicolucci A, Rossi MC, Pellegrini F, Lucisano G, Pintaudi B, Gentile S, Marra G, Skovlund SE, Vespasiani G; BENCH-D Study Group. Benchmarking network for clinical and humanistic outcomes in diabetes (BENCH-D) study: protocol, tools, and population. Springerplus. 2014;3:83.
  11. Polonsky W, Traylor L, Wei W, Shi R, Ameer B, Vlajnic A, Nicolucci A. More satisfied, but why? A pooled patient-level analysis of treatment satisfaction following the initiation of insulin glargine vs. comparators in insulin-naïve patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2014;16:255-61.
  12. Rossi MC, Nicolucci A, Lucisano G, Pellegrini F, Di Bartolo P, Miselli V, Anichini R, Vespasiani G; Did Study Group. Impact of the “Diabetes Interactive Diary” telemedicine system on metabolic control, risk of hypoglycemia, and quality of life: a randomized clinical trial in type 1 diabetes. Diabetes Technol Ther. 2013;15:670-9.
  13. Nicolucci A, Kovacs Burns K, Holt RI, Comaschi M, Hermanns N, Ishii H, Kokoszka A, Pouwer F, Skovlund SE, Stuckey H, Tarkun I, Vallis M, Wens J, Peyrot M; DAWN2 Study Group. Diabetes Attitudes, Wishes and Needs second study (DAWN2™): Cross-national benchmarking of diabetes-related psychosocial outcomes for people with diabetes. Diabet Med. 2013;30:767-77.
  14. Holt RI, Nicolucci A, Kovacs Burns K, Escalante M, Forbes A, Hermanns N, Kalra S, Massi-Benedetti M, Mayorov A, Menéndez-Torre E, Munro N, Skovlund SE, Tarkun I, Wens J, Peyrot M; DAWN2 Study Group. Diabetes Attitudes, Wishes and Needs second study (DAWN2™): Cross-national comparisons on barriers and resources for optimal care-healthcare professional perspective. Diabet Med. 2013;30:789-98.
  15. Kovacs Burns K, Nicolucci A, Holt RI, Willaing I, Hermanns N, Kalra S, Wens J, Pouwer F, Skovlund SE, Peyrot M; DAWN2 Study Group. Diabetes Attitudes, Wishes and Needs second study (DAWN2™): Cross-national benchmarking indicators for family members living with people with diabetes. Diabet Med. 2013;30:778-88.
  16. Peyrot M, Burns KK, Davies M, Forbes A, Hermanns N, Holt R, Kalra S, Nicolucci A, Pouwer F, Wens J, Willaing I, Skovlund SE. Diabetes Attitudes Wishes and Needs 2 (DAWN2): a multinational, multi-stakeholder study of psychosocial issues in diabetes and person-centred diabetes care. Diabetes Res Clin Pract. 2013;99:174-84.
  17. Nicolucci A, Balducci S, Cardelli P, Cavallo S, Fallucca S, Bazuro A, Simonelli P, Iacobini C, Zanuso S, Pugliese G; Italian Diabetes Exercise Study Investigators. Relationship of exercise volume to improvements of quality of life with supervised exercise training in patients with type 2 diabetes in a randomised controlled trial: the Italian Diabetes and Exercise Study (IDES). Diabetologia. 2012;55:579-88.
  18. Franciosi M, Caccamo L, De Simone P, Pinna AD, Di Costanzo GG, Volpes R, Scuderi V, Strignano P, Boccagni P, Burra P, Nicolucci A; TWINS I Study Group. Development and validation of a questionnaire evaluating the impact of hepatitis B immune globulin prophylaxis on the quality of life of liver transplant recipients. Liver Transpl. 2012;18:332-9
  19. Dalfrà MG, Nicolucci A, Bisson T, Bonsembiante B, Lapolla A; QLISG (Quality of Life Italian Study Group). Quality of life in pregnancy and post-partum: a study in diabetic patients. Qual Life Res. 2012;21:291-8.
  20. Nicolucci A, Balducci S, Cardelli P, Zanuso S, Pugliese G; Italian Diabetes Exercise Study (IDES) Investigators. Improvement of quality of life with supervised exercise training in subjects with type 2 diabetes mellitus. Arch Intern Med. 2011;171:1951-3.
  21. Nicolucci A, Del Prato S, Vespasiani G; ELEONOR Study Group. Optimizing insulin glargine plus one injection of insulin glulisine in type 2 diabetes in the ELEONOR study: similar effects of telecare and conventional self-monitoring of blood glucose on patient functional health status and treatment satisfaction. Diabetes Care. 2011;34:2524-6.
  22. Rossi MC, Nicolucci A, Di Bartolo P, Bruttomesso D, Girelli A, Ampudia FJ, Kerr D, Ceriello A, Mayor Cde L, Pellegrini F, Horwitz D, Vespasiani G. Diabetes Interactive Diary: a new telemedicine system enabling flexible diet and insulin therapy while improving quality of life: an open-label, international, multicenter, randomized study. Diabetes Care. 2010;33:109-15.
  23. Franciosi M, Maione A, Pomili B, Amoretti R, Busetto E, Capani F, Bruttomesso D, Di Bartolo P, Girelli A, Leonetti F, Morviducci L, Ponzi P, Vitacolonna E, Nicolucci A. Correlates of quality of life in adults with type 1 diabetes treated with continuous subcutaneous insulin injection. Nutr Metab Cardiovasc Dis. 2010;20:7-14.
  24. Dalfrà MG, Nicolucci A, Lapolla A. The effect of telemedicine on outcome and quality of life in pregnant women with diabetes. J Telemed Telecare. 2009;15:238-42.
  25. Nicolucci A, Cucinotta D, Squatrito S, Lapolla A, Musacchio N, Leotta S, Vitali L, Bulotta A, Nicoziani P, Coronel G; QuoLITy Study Group. Clinical and socio-economic correlates of quality of life and treatment satisfaction in patients with type 2 diabetes. Nutr Metab Cardiovasc Dis. 2009;19:45-53.
  26. EQuality1 Study Group–Evaluation of QUALITY of Life and Costs in Diabetes Type 1, Nicolucci A, Maione A, Franciosi M, Amoretti R, Busetto E, Capani F, Bruttomesso D, Di Bartolo P, Girelli A, Leonetti F, Morviducci L, Ponzi P, Vitacolonna E. Quality of life and treatment satisfaction in adults with Type 1 diabetes: a comparison between continuous subcutaneous insulin infusion and multiple daily injections. Diabet Med. 2008;25:213-20.
  27. Milano M, Mola E, Collecchia G, Del Carlo A, Giancane R, Visentin G, Nicolucci A. Validation of the Italian version of the EUROPEP instrument for patient evaluation of general practice care. Eur J Gen Pract. 2007;13:92-4.
  28. De Berardis G, Pellegrini F, Franciosi M, Belfiglio M, Di Nardo B, Greenfield S, Kaplan SH, Rossi MC, Sacco M, Tognoni G, Valentini M, Nicolucci A; QuED Study Group. Clinical and psychological predictors of incidence of self-reported erectile dysfunction in patients with type 2 diabetes. J Urol. 2007;177:252-7.
  29. Nicolucci A, De Berardis G, Franciosi M, Pellegrini F. Outcomes Research in Diabetes: From theory to practice. Results of the QuED Study. Drug Dev Res. 2006;67:280-6.
  30. De Berardis G, Pellegrini F, Franciosi M, Belfiglio M, Di Nardo B, Greenfield S, Kaplan SH, Rossi MCE, Sacco M, Tognoni G, Valentini M, Nicolucci A. Longitudinal assessment of quality of life in patients with type 2 diabetes and self-reported erectile dysfunction. Diabetes Care 2005; 28:1643-1649.
  31. Nicolucci A, Giorgino R, Cucinotta D, Zoppini G, Muggeo M, Squatrito S, Corsi A, Lostia S, Pappalardo L, Benaduce E, Girelli A, Galeone F, Maldonato A, Perriello G, Pata P, Marra G, Coronel GA. Validation of the Italian version of the WHO-Well-Being Questionnaire (WHO-WBQ) and the WHO-Diabetes Treatment Satisfaction Questionnaire (WHO-DTSQ). Diabetes Nutr Metab Cardiovasc Dis 2004; 17: 235-243.
  32. Franciosi M, Pellegrini F, De Berardis G, Belfiglio M, Di Nardo B, Greenfield S, Kaplan SH, Sacco M, Tognoni G, Valentini M, Nicolucci A. The QuED Study Group – Quality of Care and Outcomes in Type 2 Diabetes. Correlates of satisfaction for the relationship with their physician in type 2 diabetic patients. Diabetes Res Clin Pract 2004; 66: 277-286.
  33. De Berardis G, Pellegrini F, Franciosi M, Belfiglio M, Di Nardo B, Greenfield S, Kaplan SH, Rossi MC, Sacco M, Tognoni G, Valentini M, Nicolucci A for the Quality of Care and Outcomes in Type 2 Diabetes (QuED) Study Group Identifying type 2 diabetic patients with higher likelihood of erectile dysfunction: the role of interaction between clinical and psychological factors. Journal of Urology 2003; 169:1422-1428.
  34. De Berardis G, Franciosi M, Belfiglio M, Di Nardo B, Greenfield S, Kaplan SH, Pellegrini F, Sacco M, Tognoni G, Valentini M, Nicolucci A, for The QuED Study Group. Erectile Dysfunction and Quality of Life in Type 2 Diabetic Patients: a Serious Problem too Often Overlooked. Diabetes Care 2002; 25:284-291.
  35. Genazzani AR, Nicolucci A, Campagnoli C, Crosignani P, Nappi C, Serra GB, Bottiglioni E, Cianci A, De Aloysio D, Sarti CD, Gambacciani M, Monteleone P, Ciaponi M, Genazzani AD, Guaschino S, Palumbo G, Petraglia F, Schonauer S, Volpe A, Coronel GA, Di Paolantonio T, Nagni M, Tempesta A; Progetto Donna Qualità della Vita Working Group Novo Nordisk Italia. Validation of Italian version of the Women’s Health Questionnaire: assessment of quality of life of women from the general population and those attending menopause centers. Climacteric 2002; 5:70-7.
  36. Genazzani AR, Nicolucci A, Campagnoli C, Crosignani P, Nappi C, Serra GB, Bottiglioni E, Cianci A, De Aloysio D, Donati Sarti C, Gambacciani M, Monteleone P, Genazzani AD, Guaschino S, Palumbo G, Petraglia F, Schonauer S, Volpe A, Di Paolantonio T, Nagni M, Tempesta A, Coronel GA; Progetto Donna Qualità della Vita Working Group. Assessment of the QoL in Italian menopausal women: comparison between HRT users and non-users. Maturitas. 2002;42:267-80.
  37. Franciosi M, Pellegrini F, De Berardis G, Belfiglio M, Cavaliere D, Di Nardo B, Greenfield S, Kaplan SH, Sacco M, Tognoni G, Valentini M, Nicolucci A. The QuED Study Group – Quality of Care and Outcomes in Type 2 Diabetes The Impact of Blood Glucose Self-Monitoring on Metabolic Control and Quality of Life in Type 2 Diabetic Patients: An urgent need for better educational strategies. Diabetes Care 2001; 24: 1870-7.
  38. Nicolucci A, Ciccarone E, Consoli A, Di Martino G, La Penna G, Latorre A, Pandolfi A, Vitacolonna E, Capani F. Relationship between patient practice-oriented knowledge and metabolic control in intensively treated Type 1 diabetic patients: results of the validation of the Knowledge and Practices Diabetes Questionnaire. Diabetes, Nutrition & Metabolism 2000; 13:276-83.
  39. Carinci F, Nicolucci A, Ciampi A, Labbrozzi D, Bettinardi O, Zotti AM, Tognoni G, on behalf of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico. Role of interactions between psychological and clinical factors in determining 6-month mortality among patients with acute myocardial infarction: application of recursive partitioning techniques to the GISSI-2 data-base. European Heart Journal 1997;18: 835-45.