For over 20 years CORESEARCH team leads research activities in the field of observational epidemiology.

Main accomplishments cover:

  • Longitudinal studies
  • Case-control studies
  • Cross-sectional studies

aimed at the identification and evaluation of risk factors for chronic diseases.

Observational studies also include real world data for the evaluation of the effectiveness and safety profile of drugs when used in routine clinical practice.

Studies mainly cover the areas of diabetology, nephrology, cardiology and oncology.

Activities include development of the study protocol, statistical analysis plan, electronic and web-based CRF, coordination of the study, statistical analysis, creation of both statistical and clinical study reports and contents drafting for abstracts and scientific papers.

CORESEARCH is also acknowledged by the Italian Drug Agency (AIFA) to carry out monitoring of study activities.

 

Bibliography:

  1. Lapolla A, Berra C, Boemi M, Bossi AC, Candido R, Di Cianni G, Frontoni S, Genovese S, Ponzani P, Provenzano V, Russo GT, Sciangula L, Simioni N, Bette C, Nicolucci A; NN2211-4118 Study Group. Long-Term Effectiveness of Liraglutide for Treatment of Type 2 Diabetes in a Real-Life Setting: A 24-Month, Multicenter, Non-interventional, Retrospective Study. Adv Ther 2018; 35: 243-253.
  2. Khunti K, Godec TR, Medina J, Garcia-Alvarez L, Hiller J5,Gomes MB6, id-Ruzafa J, Charbonnel B, Fenici P, Hammar N, Hashigami K Kosiborod M, Nicolucci A, Shestakova MV, Ji L18, Pocock S. Patterns of glycaemic control in patients with type 2 diabetes mellitus initiating second-line therapy after metformin monotherapy: Retrospective data for 10 256 individuals from the United Kingdom and Germany. Diabetes Obes Metab 2018; 20: 389-399
  3. Buscemi S, Corleo D, Vasto S, Buscemi C, Massenti MF, Nuzzo D, Lucisano G, Barile AM, Rosafio G, Maniaci V, Giordano C. Factors associated with circulating concentrations of irisin in the general population cohort of the ABCD study. Inf J Obes 2017:  [Epub ahead of print]
  4. Cosmi F, Laini R, Nicolucci A. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med 2017; 376: 890.
  5. Ji L, Bonnet F, Charbonnel B, Gomes MB, Kosiborod M, Khunti K, Nicolucci A, Pocock S, Rathmann W, Shestakova MV, Shimomura I, Watada H, Fenici P, Hammar N, Hashigami K, Macaraeg G, Surmont F, Medina J. Towards an improved global understanding of treatment and outcomes in people with type 2 diabetes: Rationale and methods of the DISCOVER observational study program. J Diabetes Complications 2017; 31: 1188-1196.
  6. Simioni N, Filippi A, Scardapane M, Nicolucci A, Rossi MC, Frison V. Efficacy and Safety of Insulin Degludec for Hyperglycemia Management in Noncritical Hospitalized Patients with Diabetes: An Observational Study. Diabetes Ther 2017; 8: 941-946.
  7. Giorda CB, Forlani G, Manti R, Mazzotti A, De Cosmo S, Rossi MC, Nicolucci A, Di Bartolo P, Ceriello A, Guida P, Tartaglino B, Russo G; AMD-Annals Study Group. Trend over time in hepatic fibrosis score in a cohort of type 2 diabetes patients. Diabetes Res Clin Pract 2017; 135: 65-72.
  8. Saglimbene V, Natale P, Palmer S, Scardapane M, Craig JC, Ruospo M, Gargano L, Lucisano G, Török M, Celia E, Gelfman R, Bednarek-Skublewska A, Dulawa J, Stroumza P, Leal M, Del Castillo D, Murgo AM, Schon S, Wollheim C, Hegbrant J, Strippoli GFM. The prevalence and correlates of low sexual functioning in women on hemodialysis: A multinational, cross-sectional stud PLoS One 2017; 12: e0179511.
  9. Giorda C, Forlani G, Manti R, Mazzella N, De Cosmo S, Rossi MC, Nicolucci A, Russo G, Di Bartolo P, Ceriello A, Guida P; AMD-Annals Study Group. Occurrence over time and regression of nonalcoholic fatty liver disease in type 2 diabetes. Diabetes Metab Res Rev 2017; 33: doi: 10.1002/dmrr.2878.
  10. Ceriello A, De Cosmo S, Rossi MC, Lucisano G, Genovese S, Pontremoli R, Fioretto P, Giorda C, Pacilli A, Viazzi F, Russo G, Nicolucci A; AMD-Annals Study Group. Variability in HbA1c, blood pressure, lipid parameters and serum uric acid, and risk of development of chronic kidney disease in type 2 diabetes. Diabetes Obes Metab 2017; 19: 1570-1578.
  11. Quaglietta A, Di Saverio M, Lucisano G, Accorsi P, Nicolucci A. Development of the Platelet Efficacy Score (PEscore) to predict the efficacy of platelet transfusion in oncohematologic patients. Transfusion. 2017 Apr;57(4):905-912. doi: 10.1111/trf.13997. Epub 2017 Feb 24.
  12. Marzona I, Avanzini F, Lucisano G, Tettamanti M, Baviera M, Nicolucci A, Roncaglioni MC; Risk & Prevention Collaborative Group. Are all people with diabetes and cardiovascular risk factors or microvascular complications at very high risk? Findings from the Risk and Prevention Study. Acta Diabetol. 2017 Feb;54(2):123-131. doi: 10.1007/s00592-016-0899-0. Epub 2016 Oct 7.
  13. Rossi MC, Lucisano G, Pintaudi B, Bulotta A, Gentile S, Scardapane M, Skovlund SE, Vespasiani G, Nicolucci A; BENCH-D Study Group. The complex interplay between clinical and person-centered diabetes outcomes in the two genders. Health Qual Life Outcomes. 2017 Feb 21;15(1):41. doi: 10.1186/s12955-017-0613-0.
  14. Rondinelli M, Rossi A, Gandolfi A, Saponaro F, Bucciarelli L, Adda G, Molinari C, Montefusco L, Specchia C, Chiara Rossi M, Scardapane M, Arosio M, Genovese S. Use of Liraglutide in the Real World and Impact at 36 Months on Metabolic Control, Weight, Lipid Profile, Blood Pressure, Heart Rate, and Renal Function. Clin Ther. 2017 Jan;39(1):159-169.
  15. Giorda CB, Rossi MC, Ozzello O, Gentile S, Aglialoro A, Chiambretti A, Baccetti F, Gentile FM, Romeo F, Lucisano G, Nicolucci A; HYPOS-1 Study Group of  AMD. Healthcare resource use, direct and indirect costs of hypoglycemia in type  1 and type 2 diabetes, and nationwide projections: Results of the HYPOS-1 study.  Nutr Metab Cardiovasc Dis. 2016 Nov 18. pii: S0939-4753(16)30186-7.
  16. De Cosmo S, Viazzi F, Pacilli A, Giorda C, Ceriello A, Gentile S, Russo G, Rossi MC, Nicolucci A, Guida P, Feig D, Johnson RJ, Pontremoli R; AMD-Annals Study Group. Serum Uric Acid and Risk of CKD in Type 2 Diabetes. Clin J Am Soc Nephrol. 2015;10:1921-9
  17. Durante C, Costante G, Lucisano G, Bruno R, Meringolo D, Paciaroni A, Puxeddu E, Torlontano M, Tumino S, Attard M, Lamartina L, Nicolucci A, Filetti S. The natural history of benign thyroid nodules. JAMA. 2015;313:926-35.
  18. Giorda CB, Ozzello A, Gentile S, Aglialoro A, Chiambretti A, Baccetti F, Gentile FM, Lucisano G, Nicolucci A, Rossi MC; HYPOS-1 Study Group of AMD. Incidence and risk factors for severe and symptomatic hypoglycemia in type 1 diabetes. Results of the HYPOS-1 study. Acta Diabetol. 2015;52:845-53.
  19. Pintaudi B, Lucisano G, Pellegrini F, D’Ettorre A, Lepore V, De Berardis G, Scardapane M, Di Vieste G, Rossi MC, Sacco M, Tognoni G, Nicolucci A. The long-term effects of stillbirth on women with and without gestational diabetes: a population-based cohort study. Diabetologia. 2015;58:67-74.
  20. Iaffaldano P, Lucisano G, Pozzilli C, Brescia Morra V, Ghezzi A, Millefiorini E, Patti F, Lugaresi A, Zimatore GB, Marrosu MG, Amato MP, Bertolotto A, Bergamaschi R, Granella F, Coniglio G, Tedeschi G, Sola P, Lus G, Ferrò MT, Iuliano G, Corea F, Protti A, Cavalla P, Guareschi A, Rodegher M, Paolicelli D, Tortorella C, Lepore V, Prosperini L, Saccà F, Baroncini D, Comi G, Trojano M; Italian iMed-Web database. Fingolimod versus interferon beta/glatiramer acetate after natalizumab suspension in multiple sclerosis. Brain. 2015 Nov;138(Pt 11).
  21. Russo GT, Giorda CB, Cercone S, Nicolucci A, Cucinotta D; BetaDecline Study Group. Factors associated with beta-cell dysfunction in type 2 diabetes: the BETADECLINE study. PLoS One. 2014 Oct 27;9(10):e109702.
  22. Pugliese G, Solini A, Bonora E, Fondelli C, Orsi E, Nicolucci A, Penno G; RIACE Study Group. Chronic kidney disease in type 2 diabetes: Lessons from the Renal Insufficiency And Cardiovascular Events (RIACE) Italian Multicentre Study. Nutr Metab Cardiovasc Dis. 2014 24:815-22.
  23. Buscemi S, Sprini D, Grosso G, Galvano F, Nicolucci A, Lucisano G, Massenti FM, Amodio E, Rini GB. Impact of lifestyle on metabolic syndrome in apparently healthy people. Eat Weight Disord. 2014;19:225-32.
  24. Cherubini V, Pintaudi B, Rossi MC, Lucisano G, Pellegrini F, Chiumello G, Frongia AP, Monciotti C, Patera IP, Toni S, Zucchini S, Nicolucci A; SHIP-D Study Group. Severe hypoglycemia and ketoacidosis over one year in Italian pediatric population with type 1 diabetes mellitus: a multicenter retrospective observational study. Nutr Metab Cardiovasc Dis. 2014;24:538-46.
  25. Buscemi S, Nicolucci A, Lucisano G, Galvano F, Grosso G, Belmonte S, Sprini D, Migliaccio S, Cianferotti L, Brandi ML, Rini GB. Habitual fish intake and clinically silent carotid atherosclerosis. Nutr J. 2014;13:2.
  26. De Cosmo S, Rossi MC, Pellegrini F, Lucisano G, Bacci S, Gentile S, Ceriello A, Russo G, Nicolucci A, Giorda C, Viazzi F, Pontremoli R; AMD-Annals Study Group. Kidney dysfunction and related cardiovascular risk factors among patients with type 2 diabetes. Nephrol Dial Transplant. 2014;29:657-62.
  27. Buscemi S, Nicolucci A, Lucisano G, Galvano F, Grosso G, Massenti FM, Amodio E, Bonura A, Sprini D, Rini GB. Impact of chronic diuretic treatment on glucose homeostasis. Diabetol Metab Syndr. 2013;5:80.
  28. Pintaudi B, Di Vieste G, Corrado F, Lucisano G, Pellegrini F, Giunta L, Nicolucci A, D’Anna R, Di Benedetto A. Improvement of selective screening strategy for gestational diabetes through a more accurate definition of high-risk groups. Eur J Endocrinol. 2013;170:87-93.
  29. Buscemi S, Nicolucci A, Mattina A, Rosafio G, Massenti FM, Lucisano G, Galvano F, Amodio E, Pellegrini F, Barile AM, Maniaci V, Grosso G, Verga S, Sprini D, Rini GB. Association of dietary patterns with insulin resistance and clinically silent carotid atherosclerosis in apparently healthy people. Eur J Clin Nutr. 2013;67:1284-90.
  30. Penno G, Solini A, Bonora E, Fondelli C, Orsi E, Zerbini G, Trevisan R, Vedovato M, Gruden G, Laviola L, Nicolucci A, Pugliese G; the Renal Insufficiency And Cardiovascular Events (RIACE) study, group. Gender differences in cardiovascular disease risk factors, treatments and complications in patients with type 2 diabetes: the RIACE Italian multicentre study. J Intern Med. 2013;274:176-91
  31. Penno G, Solini A, Bonora E, Fondelli C, Orsi E, Zerbini G, Morano S, Cavalot F, Lamacchia O, Laviola L, Nicolucci A, Pugliese G; Renal Insufficiency And Cardiovascular Events Study Group. HbA1c variability as an independent correlate of nephropathy, but not retinopathy, in patients with type 2 diabetes: the Renal Insufficiency And Cardiovascular Events (RIACE) Italian multicenter study. Diabetes Care. 2013;36:2301-10.
  32. Penno G, Solini A, Zoppini G, Orsi E, Zerbini G, Trevisan R, Gruden G, Cavalot F, Laviola L, Morano S, Nicolucci A, Pugliese G; Renal Insufficiency And Cardiovascular Events (RIACE) Study Group. Rate and determinants of association between advanced retinopathy and chronic kidney disease in patients with type 2 diabetes: the Renal Insufficiency And Cardiovascular Events (RIACE) Italian multicenter study. Diabetes Care. 2012;35:2317-23.
  33. Pugliese G, Solini A, Zoppini G, Fondelli C, Zerbini G, Vedovato M, Cavalot F, Lamacchia O, Buzzetti R, Morano S, Nicolucci A, Penno G; Renal Insufficiency and Cardiovascular Events (RIACE) Study Group. High prevalence of advanced retinopathy in patients with type 2 diabetes from the Renal Insufficiency And Cardiovascular Events (RIACE) Italian Multicenter Study. Diabetes Res Clin Pract. 2012;98:329-37.
  34. Solini A, Penno G, Bonora E, Fondelli C, Orsi E, Arosio M, Trevisan R, Vedovato M, Cignarelli M, Andreozzi F, Nicolucci A, Pugliese G; Renal Insufficiency And Cardiovascular Events (RIACE) Study Group. Diverging association of reduced glomerular filtration rate and albuminuria with coronary and noncoronary events in patients with type 2 diabetes: the renal insufficiency and cardiovascular events (RIACE) Italian multicenter study. Diabetes Care. 2012;35:143-9.
  35. Strippoli GF; Collaborative Depression and Sexual Dysfunction (CDS) in Hemodialysis Working Group, Vecchio M, Palmer S, De Berardis G, Craig J, Lucisano G, Johnson D, Pellegrini F, Nicolucci A, Sciancalepore M, Saglimbene V, Gargano L, Bonifati C, Ruospo M, Navaneethan SD, Montinaro V, Stroumza P, Zsom M, Torok M, Celia E, Gelfman R, Bednarek-Skublewska A, Dulawa J, Graziano G, Gentile G, Ferrari JN, Santoro A, Zucchelli A, Triolo G, Maffei S, Hegbrant J, Wollheim C, De Cosmo S, Manfreda VM. Sexual dysfunction in women with ESRD requiring hemodialysis. Clin J Am Soc Nephrol. 2012 Jun;7(6):974-81.
  36. Collaborative Depression and Sexual Dysfunction in Hemodialysis Working Group, Vecchio M, Palmer S, De Berardis G, Craig J, Johnson D, Pellegrini F, Nicolucci A, Sciancalepore M, Saglimbene V, Gargano L, Bonifati C, Ruospo M, Navaneethan SD, Montinaro V, Stroumza P, Zsom M, Torok M, Celia E, Gelfman R, Bednarek-Skublewska A, Dulawa J, Graziano G, Lucisano G, Gentile G, Ferrari JN, Santoro A, Zucchelli A, Triolo G, Maffei S, Hegbrant J, Wollheim C, De Cosmo S, Manfreda VM, Strippoli GF. Prevalence and correlates of erectile dysfunction in men on chronic haemodialysis: a multinational cross-sectional study. Nephrol Dial Transplant. 2012 Jun;27(6):2479-88.
  37. Penno G, Solini A, Bonora E, Fondelli C, Orsi E, Zerbini G, Trevisan R, Vedovato M, Gruden G, Cavalot F, Cignarelli M, Laviola L, Morano S, Nicolucci A, Pugliese G; Renal Insufficiency And Cardiovascular Events (RIACE) Study Group. Clinical significance of nonalbuminuric renal impairment in type 2 diabetes. J Hypertens. 2011;29:1802-9.
  38. Nicolucci A. Fact and figures about diabetes in Italy. Assist Inferm Ric. 2011;30:100-6.
  39. Pugliese G, Solini A, Bonora E, Orsi E, Zerbini G, Giorgino F, Cavalot F, Pontiroli AE, Baroni MG, Morano S, Nicolucci A, Penno G. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation provides a better definition of cardiovascular burden associated with CKD than the Modification of Diet in Renal Disease (MDRD) Study formula in subjects with type 2 diabetes. Atherosclerosis. 2011;218:194-9.
  40. Pugliese G, Solini A, Fondelli C, Trevisan R, Vedovato M, Nicolucci A, Penno G; for the Renal Insufficiency And Cardiovascular Events (RIACE) Study Group. Reproducibility of albuminuria in type 2 diabetic subjects. Findings from the Renal Insufficiency And Cardiovascular Events (RIACE) Study. Nephrol Dial Transplant. 2011; 26:3950-4.
  41. Chiodini BD, Specchia C, Gori F, Barlera S, D’Orazio A, Pietri S, Crociati L, Nicolucci A, Franciosi M, Signorini S, Brambilla P, Grazia Franzosi M; GISSI Prevenzione Investigators; SiBioC-GISSI Prevenzione Group. Adiponectin gene polymorphisms and their effect on the risk of myocardial infarction and type 2 diabetes: an association study in an Italian population. Ther Adv Cardiovasc Dis. 2010;4:223-30.
  42. Gori F, Specchia C, Pietri S, Crociati L, Barlera S, Franciosi M, Nicolucci A, Signorini S, Brambilla P, Franzosi MG; GISSI Prevenzione Investigators; SIBioC-GISSI Prevenzione Group. Common genetic variants on chromosome 9p21 are associated with myocardial infarction and type 2 diabetes in an Italian population. BMC Med Genet. 2010;11:60.
  43. Nicolucci A. Epidemiological aspects of neoplasms in diabetes. Acta Diabetol. 2010;47:87-95
  44. Rossi MC, Nicolucci A, Pellegrini F, Comaschi M, Ceriello A, Cucinotta D, Giorda C, Pomili B, Valentini U, Vespasiani G, De Cosmo S. Obesity and changes in urine albumin/creatinine ratio in patients with type 2 diabetes: the DEMAND study. Nutr Metab Cardiovasc Dis. 2010;20:110-6.
  45. Greenfield S, Billimek J, Pellegrini F, Franciosi M, De Berardis G, Nicolucci A, Kaplan SH. Comorbidity affects the relationship between glycemic control and cardiovascular outcomes in diabetes: a cohort study. Ann Intern Med. 2009;151:854-60.
  46. Di Bartolomeo P, Santarone S, Di Bartolomeo E, Olioso P, Bavaro P, Papalinetti G, Di Carlo P, Papola F, Nicolucci A, Di Nicola M, Iacone A. Long-term results of survival in patients with thalassemia major treated with bone marrow transplantation. Am J Hematol. 2008;83:528-30.
  47. Rossi MC, Nicolucci A, Pellegrini F, Comaschi M, Ceriello A, Cucinotta D, Giorda C, Valentini U, Vespasiani G, De Cosmo S. Identifying patients with type 2 diabetes at high risk of microalbuminuria: results of the DEMAND (Developing Education on Microalbuminuria for Awareness of reNal and cardiovascular risk in Diabetes) Study. Nephrol Dial Transplant. 2008;23:1278-84.
  48. Pupillo M, De Berardis G, Antenucci D, Minnucci A, Nicolucci A. Glycated haemoglobin or mean blood glucose as indicators of metabolic control in Type 2 diabetes? Diabetes Res Clin Pract. 2008 Jun;80(3):e1-3.
  49. Franciosi M, Pellegrini F, Sacco M, De Berardis G, Rossi MC, Strippoli GF, Belfiglio M, Tognoni G, Valentini M, Nicolucci A; IGLOO (Impaired Glucose tolerance, and Long-term Outcomes Observational Study) Study Group. Identifying patients at risk for microalbuminuria via interaction of the components of the metabolic syndrome: a cross-sectional analytic study. Clin J Am Soc Nephrol. 2007;2:984-91.
  50. Comaschi M, Coscelli C, Cucinotta D, Malini P, Manzato E, Nicolucci A; on behalf of the SFIDA Study Group – Italian Association of Diabetologists (AMD). Cardiovascular risk factors and metabolic control in type 2 diabetic subjects attending outpatient clinics in Italy: The SFIDA (survey of risk factors in Italian diabetic subjects by AMD) study. Nutr Metab Cardiovasc Dis. 2005;15:204-11.
  51. Franciosi M, De Berardis G, Rossi MCE, Sacco M, Belfiglio M, Pellegrini F, Tognoni G, Valentini M, Nicolucci A. The use of the Diabetes Risk Score for Opportunistic Screening of Undiagnosed Diabetes and Impaired Glucose Tolerance. The IGLOO (Impaired Glucose Tolerance and Long-Term Outcomes Observational Study) Study. Diabetes Care 2005;28:1187-94.
  52. Palazzi C, Olivieri I, D’Amico E, D’Agostino L, Nicolucci A, Pennese E, Petricca A. Hepatitis C virus infection in psoriatic arthritis. Arthritis Rheum. 2005;53:223-5.
  53. Angelucci E, Muretto P, Nicolucci A, Baronciani D, Erer B, Gaziev J, Ripalti M, Sodani P, Tomassoni S, Visani G, and Lucarelli G. Effects of iron overload and hepatitis C virus positivity in determining progression of liver fibrosis in thalassemia following bone marrow transplantation. Blood 2002; 100:17-21.
  54. Fresco C, Carinci F, Maggioni AP, Ciampi A, Nicolucci A, Santoro E, Tavazzi L, Tognoni G, on behalf of the GISSI Investigators. Very early assessment of risk for in-hospital death among 11,483 patients with acute myocardial infarction. American Heart Journal 1999; 138:1058-64.
  55. El-Shazly M, Abdel-Fattah M, Scorpiglione N, Massi Benedetti M, Capani F, Carinci F, Carta Q, Cavaliere D, De Feo EM, Taboga C, Tognoni G, Nicolucci A, on behalf of the Italian Study Group for the Implementation of the St Vincent Declaration. Risk factors for lower limb complications in diabetic patients. Journal of Diabetes and its Complications 1998; 12: 10-17.
  56. Nicolucci A, Carinci F, Ciampi A, on behalf of the SID-AMD Italian Study Group for the Impementation of the St Vincent Declaration. Stratifying patients at risk of diabetic complications: an integrated look at clinical, socio-economic and care-related factors. Diabetes Care 1998; 21: 1439-44.
  57. Carinci F, Nicolucci A, Ciampi A, Labbrozzi D, Bettinardi O, Zotti AM, Tognoni G, on behalf of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico. Role of interactions between psychological and clinical factors in determining 6-month mortality among patients with acute myocardial infarction: application of recursive partitioning techniques to the GISSI-2 data-base. European Heart Journal 1997;18: 835-45.
  58. Nicolucci A, Cavaliere D, Scorpiglione N, Carinci F, Capani F, Tognoni G, Massi Benedetti M, The SID-AMD Italian Study Group for the Implementation of the St Vincent Declaration. A comprehensive assessment of the avoidability of long term complications of diabetes mellitus: a case-control study. Diabetes Care 1996; 19:927-33.