CORESEARCH epidemiologists have been forerunners in Italy in the promotion of Evidence Based Medicine, the applicationf of systematic reviews and meta-analyses techniques the and critical assessment of scientific evidences (critical appraisal).

The first international systematic review and meta-analysis in the field of diabetes has been headed and coordinated by Dr. Nicolucci and his team and published in the Cochrane Database of Systematic Reviews.

Currently CORESEARCH leads meta-analyses of randomized clinical trials and observational studies, by applying frequentist and Bayesian techniques, as well as the most recent techniques of meta-regression and network meta-analysis.



  1. Broglio F, Mannucci E, Napoli R, Nicolucci A, Purrello F, Nikonova E, Stager W, Trevisan R. Beneficial effect of lixisenatide after 76 weeks of treatment in patients with type 2 diabetes mellitus: A meta-analysis from the GetGoal programme. Diabetes Obes Metab 2017; 19: 248-256.
  2. Wu Y, Yao X, Vespasiani G, Nicolucci A, Dong Y, Kwong J, Li L, Sun X, Tian H, Li S. Mobile App-Based Interventions to Support Diabetes Self-Management: A Systematic Review of Randomized Controlled Trials to Identify Functions Associated with Glycemic Efficacy. JMIR Mhealth Uhealth. 2017 Mar 14;5(3):e35. doi: 10.2196/mhealth.6522.
  3. Palmer SC, Teixeira-Pinto A, Saglimbene V, Craig JC, Macaskill P, Tonelli M, De Berardis G, Ruospo M, Strippoli GF. Association of Drug Effects on Serum Parathyroid Hormone, Phosphorus, and Calcium Levels With Mortality in CKD: A Meta-analysis. Am J Kidney Dis. 2015 Dec;66(6):962-71.
  4. Polonsky W, Traylor L, Wei W, Shi R, Ameer B, Vlajnic A, Nicolucci A. More satisfied, but why? A pooled patient-level analysis of treatment satisfaction following the initiation of insulin glargine vs. comparators in insulin-naïve patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2014;16:255-61.
  5. Franciosi M, Lucisano G, Lapice E, Strippoli GF, Pellegrini F, Nicolucci A. Metformin therapy and risk of cancer in patients with type 2 diabetes: systematic review. PLoS One. 2013;8:e71583.
  6. Palmer SC, Vecchio M, Craig JC, Tonelli M, Johnson DW, Nicolucci A, Pellegrini F, Saglimbene V, Logroscino G, Hedayati SS, Strippoli GF. Association between depression and death in people with CKD: a meta-analysis of cohort studies. Am J Kidney Dis. 2013;62:493-505.
  7. Palmer SC, Di Micco L, Razavian M, Craig JC, Ravani P, Perkovic V, Tognoni G, Graziano G, Jardine M, Pellegrini F, Nicolucci A, Webster A, Strippoli GF. Antiplatelet therapy to prevent hemodialysis vascular access failure: systematic review and meta-analysis. Am J Kidney Dis. 2013;61:112-22.
  8. Palmer S, Vecchio M, Craig JC, Tonelli M, Johnson DW, Nicolucci A, Pellegrini F, Saglimbene V, Logroscino G, Fishbane S, Strippoli GF. Prevalence of depression in chronic kidney disease: systematic review and meta-analysis of observational studies. Kidney Int. 2013;84:179-91.
  9. Palmer SC, Di Micco L, Razavian M, Craig JC, Perkovic V, Pellegrini F, Copetti M, Graziano G, Tognoni G, Jardine M, Webster A, Nicolucci A, Zoungas S, Strippoli GF. Effects of antiplatelet therapy on mortality and cardiovascular and bleeding outcomes in persons with chronic kidney disease: a systematic review and meta-analysis. Ann Intern Med. 2012;156:445-59.
  10. Maione A, Navaneethan SD, Graziano G, Mitchell R, Johnson D, Mann JF, Gao P, Craig JC, Tognoni G, Perkovic V, Nicolucci A, De Cosmo S, Sasso A, Lamacchia O, Cignarelli M, Manfreda VM, Gentile G, Strippoli GF. Angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and combined therapy in patients with micro- and macroalbuminuria and other cardiovascular risk factors: a systematic review of randomized controlled trials. Nephrol Dial Transplant. 2011;26:2827-47.
  11. Palmer SC, Navaneethan SD, Craig JC, Johnson DW, Tonelli M, Garg AX, Pellegrini F, Ravani P, Jardine M, Perkovic V, Graziano G, McGee R, Nicolucci A, Tognoni G, Strippoli GF. Meta-analysis: erythropoiesis-stimulating agents in patients with chronic kidney disease. Ann Intern Med. 2010;153:23-33.
  12. De Berardis G, Sacco M, Strippoli GF, Pellegrini F, Graziano G, Tognoni G, Nicolucci A. Aspirin for primary prevention of cardiovascular events in people with diabetes: meta-analysis of randomised controlled trials. BMJ. 2009;339:b4531.
  13. Strippoli GF, Navaneethan SD, Johnson DW, Perkovic V, Pellegrini F, Nicolucci A, Craig JC. Effects of statins in patients with chronic kidney disease: meta-analysis and meta-regression of randomised controlled trials. BMJ. 2008;336:645-51.
  14. Nicolucci A, Tognoni G. Should we trust results of meta-analyses? Lancet 2004; 364: 1401.
  15. Nicolucci A, Carinci F, Cavaliere D, Scorpiglione N, Belfiglio M, Labbrozzi D, Mari E, Massi Benedetti M, Tognoni G, Liberati A, on behalf of the Italian Study Group for the Implementation of St Vincent Declaration. A Meta-Analysis of trials on aldose reductase inhibitors in diabetic peripheral neuropathy. Diabetic Medicine 1996; 13:1017-26.
  16. Nicolucci A, Carinci F, Graepel JG, Hohman TC, Ferris F, Lachin JM. The efficacy of tolrestat in the treatment of diabetic peripheral neuropathy: a meta-analysis of individual patient data. Diabetes Care 1996; 19:1091-96.
  17. Cavaliere D, Scorpiglione N, Belfiglio M, Carinci F, Cubasso D, Labbrozzi D, Mari E, Massi Benedetti M, Pontano C, Tognoni G, Nicolucci A, on behalf of the Study Group for the Application of the St Vincent Declaration. Quality assessment of randomised clinical trials on medical treatment of diabetic neuropathy. Diabetes, Nutrition & Metabolism 1994; 7: 287-94.
  18. Nicolucci A, Grilli R, Alexanian A, Apolone G, Torri W, Liberati A. Quality, evolution and clinical implications of randomized, controlled trials on the treatment of lung cancer. A lost opportunity for meta-analysis. JAMA 1989; 262:2101-7.